A Phase 2 Study of the Efficacy of Antioxidant Therapy Compared With Enalapril in Slowing the Progression of Sickle Nephropathy in Children

Study point of contact

Lesley King, MB.BS
976-927-2471
[email protected]

Locations

1 Jamaica site

Age

2 to 18 Years

Phase

N/A

Study type

Interventional

Gender

All

Interventions

Drug

Compensation

Unknown

About the study

The purpose of this study is to determine whether enalapril or antioxidant therapy
(N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell
disease and and its progression to sickle nephropathy

participation requirements

– Homozygous S sickle cell disease

– Diagnosed by newborn screening

– determined to have persistent microalbuminuria

– satisfied criteria for microalbuminuria screening

– parental consent

participation restrictions

– Asymptomatic bacteriuria on screening urine cultures

– On Hydroxyurea therapy

– Pre-existing complications of SCD which would meet local criteria for HU therapy

Locations

  • Kingston, Jamaica, Sickle Cell Unit