Assessment of Liver Fibrosis in Patients With Sickle Cell Disease

Locations

1 United States site

Age

10 to 65 Years

Study type

Observational

Gender

All

Interventions

Other

Procedure

Compensation

Unknown

About the study

Patients with sickle cell disease many have a number of systemic complications, including
liver problems. Some of these liver problems lead to liver fibrosis/cirrhosis, secondary to
chronic blood transfusions. The purpose of this study is to investigate FibroScan readings in
patients with sickle cell disease and iron overload secondary to blood transfusions, and to
correlate the FibroScan results with Ferriscan. A comparison with the results of FibroScan to
patients with Sickle cell without known liver disease, who have never been on chronic
transfusions and with normal liver function profiles will also be made.The primary hypothesis
is that the results of FibroScan will correlate with the results of Ferriscan and liver
biopsy.

participation requirements

– pediatric patients age 10 years and older with sickle cell disease

– meeting other criteria:

1. history of chronic transfusion and iron overload and/or

2. known liver disease related to sickle cell or iron overload

– signed consent and assent (as applicable)

participation restrictions

– children younger than 10 years

– Pregnant females

– Prisoners

– Other causes of liver disease, unrelated to sickle cell or iron overload

Locations

  • Miami, Florida, United States, University of Miami, 33136