Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy

About the study

Background:

Sickle cell disease is a common inherited blood disorder. Kidney disease is a major cause of
problems in people with sickle cell disease. In order to identify kidney problems early and
stop the progression of kidney disease, doctors need the most accurate tests to check kidney
function. Researchers hope to understand more about how to test for kidney disease in people
with sickle cell disease.

Objective:

To determine which of two different lab tests is the best to measure kidney function in
adults with sickle cell disease.

Eligibility:

People 18 years and older who have sickle cell disease

Design:

Participants will be screened with a medical history and blood tests.

Participants will have up to 3 visits.

Participants will collect their urine in a special container over 24 hours.

At the first visit, participants will have blood tests. They will bring their container of
urine to the visit. They will have an iothalamate test. For the test, they will get a
catheter: a small tube will be inserted into a vein. A special contract agent will be
injected into the vein. Blood will be collected over the next 4 hours to test kidney
function.

Participants will return the next day for a second visit. They will have blood tests. They
will have an MRI. For the MRI, they will like on a table that slides into a machine that
takes pictures of the kidneys. They may have the MRI in a third visit.

Study point of contact

Julia M Varga
(301) 402-3595
[email protected]

Locations

1 United States site

Age

18 to 99 Years

Genotypes

Hb SS

Study type

Observational

Gender

All

Compensation

Unknown

participation requirements

Known diagnosis of Sickle Cell Anemia (Hb SS or HbS-beta0-thal) >=18 years of age

Willingness and capacity to provide written informed consent

participation restrictions

Pregnancy

Uncontrolled/poorly controlled hypertension

Diabetes

Dialysis

GFR <30 ml/min/1.73m2 HIV positive HepatitisC Hepatitis B Prior transplantation Uncontrolled infection or acute illness Chronic inflammatory disease (e.g. lupus, multiple sclerosis, rheumatoid arthritis) Allergy to iodine or iodinated contrast solutions Hydroxyurea initiation or dose adjustment <2mo prior Initiation of chronic transfusion therapy <2mo prior Antihypertensive medication initiation or dose adjustment <1mo prior Pain crisis in preceding 4weeks

Locations

  • Bethesda, Maryland, United States, National Institutes of Health Clinical Center, 20892 [Recruiting]
Last updated 2021-08-27