Cerebrovascular Reserve Measurements in Sickle Cell Disease: an MRI Study

Study point of contact

BJ Biemond
[email protected]

Locations

1 Netherlands site

Age

> 18 Years

Genotypes

HbSS

Study type

Observational

Gender

All

Interventions

Drug

Compensation

Unknown

About the study

The primary aim of this study is to evaluate MRI-based cerebrovascular reserve (CVR)
measurements in adult patients with Sickle Cell Disease (SCD).

The primary objective is to assess whether there is a correlation between CVR and silent
cerebral infarcts (SCIs).

participation requirements

Patient group:

– Sickle cell disease; either homozygous sickle cell disease (HbSS), or HbSβ0
thalassemia

– 18 years of age or older

– Informed consent

Inclusion Criteria Control group:

– Similar ethnic background as Patient group

– 18 years of age or older

– Informed consent

participation restrictions

Patient group and Control group:

– Inability of the patient to provide informed consent or legally
incompetent/incapacitated to do so

– Contraindications for MRI, such as pregnancy, claustrophobia or the presence of metal
in the body

– Sickle cell crisis at the moment of participation

– History of cerebral pathology that compromises measurements, such as cerebral palsy,
brain tumour,meningitis, overt infarct

– Brain surgery performed in the last 3 months

– Severe liver, heart or renal dysfunction (clearance < 10 mL/min) - Allergy to sulphonamide - Breastfeeding - Use of phenytoin, procaine or acetylsacylic acid ("Ascal/aspirin") - Risk of hypokalaemia (use of diuretics, primary hyperaldosteronism) - Addison's Disease - Severe asthma or emphysema

Locations

  • Amsterdam, Netherlands, Academic Medical Center [Recruiting]