49 United States sites
Patients fulfilling the inclusion criteria will be eligible for enrollment in this study.
Of those who consent, only patients who lack a suitable HLA-identical or 1 allele or
antigen mismatched related donors are evaluable. Patients with an HLA-identical sibling or
1 allele or antigen mismatched family member donor are evaluable as long as the center
deems the family member donor as unsuitable for other reasons. Patients may co-enroll with
other interventional or observational studies.
1. Patients of all ages with AML, ALL, MDS, NHL, HL, AA, or SCD are eligible.
2. Any planned conditioning regimen and GVHD prophylaxis approach is eligible.
3. Patients must be considered suitable allogeneic transplant candidates at the time of
enrollment based on medical history, physical examination, and available laboratory
tests. Specific testing for organ function is not required for eligibility but, if
available, these tests should be used by the treating physician to judge transplant
4. Patient and physician must intend to proceed with allogeneic HCT within the next 6
months if a suitable donor is identified.
5. Center plans to follow the algorithm for alternative donor identification: (a) for
subjects who are Very Likely to find a MUD, attempt to identify a matched unrelated
donor; (b) for a subjects who are Very Unlikely to find a MUD, proceed expeditiously
to a haploidentical, cord blood or mismatched unrelated donor.
6. Signed informed consent, and assent if applicable. Consent may be signed prior to
completion of family typing but patients will only be considered evaluable upon
confirmation that there is no suitable HLA-identical or 1 allele or antigen mismatched
related donor available.
1. Prior allogeneic HCT (prior autologous transplant is allowed)
2. Previous formal unrelated donor search