Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Adult Patients With Sickle-cell Disease Hospitalized for Acute Chest Syndrome. A Bi-centric, Open, Parallel-group, Randomized Controlled Study

Study point of contact

Guillaume VOIRIOT, MD
01 56 01 65 74
[email protected]
Muriel FARTOUKH, PU-PH
01 56 01 65 74
[email protected]

Locations

1 France site

Age

> 18 Years

Phase

N/A

Study type

Interventional

Gender

All

Interventions

Procedure

Compensation

Unknown

About the study

Many patients with Sickle Cell Disease (SCD) may develop Acute Chest Syndrome (ACS). ACS is
usually caused by a Lower respiratory tract infection (LRTI) which may be caused by either a
bacterium or a virus. Antibiotics are usually used for 7 to 10 days with no microbiological
workup.

The hypothesize of the study is that the identification of the microorganisms might lead to a
reduction of antibiotics exposure and a better care of the patients.

We speculate that an early pathogen-directed strategy (respiratory broad panel multiplex PCR
and early antibiotics interruption based on the PCT values decrease) might reduce the
antibiotics exposure in SCD patients with ACS who are hospitalized and for whom an antibiotic
treatment is indicated, as compared with usual care

participation requirements

– Age ≥ 18 years

– Sickle Cell Disease patients with ACS with an antibiotic therapy indication

– Signed and informed consent

– Affiliated with social security

participation restrictions

Documented extra-pulmonary bacterial infection at the time of inclusion;

– Patients who received antibiotics for more than 24 hours before the diagnosis of ACS
(during the primary hospitalization)

– Known severe immunosuppression (AIDS, neutropenia (<1000 PNN), hematology, solid tumor under chemotherapy, transplanted organ); long-term treatment with hydroxy-carbamide is not considered - Pregnant or lactating women; - Person deprived of liberty or under legal protection; - Participation in another interventional study of type Jardé 1

Locations

  • Paris, France, Service de Réanimation et USC médico-chirurgicale, 75020 [Recruiting]
Last updated 2021-02-15 Enroll Now