About the study
Three methods are actually used in newborn screening for sickle cell disease (SCD) in France:
isoelectric focusing, high performance liquid chromatography and capillary electrophoresis.
New technologies are currently under development such as Matrix Assisted Laser Desorption
Ionisation – Time of Flight (MALDI-TOF) and tandem mass spectrometry (MS/MS) using the SpOtOn
Diagnostics Reagent Kit available in United Kingdom only.
Zentech company (Liège, Belgium) is developing a package for SCD newborn screening using
MS/MS technology. The main objective of the present study will be to compare this new
technique with the technique actually used in the hospital center of Lille (sub-contractor
for SCD newborn screening of Lyon) and the haemoglobin analysis to test its accuracy
(sensitivity and specificity).