Three methods are actually used in newborn screening for sickle cell disease (SCD) in France: isoelectric focusing, high performance liquid chromatography and capillary electrophoresis. New technologies are currently under development such as Matrix Assisted Laser Desorption Ionisation – Time of Flight (MALDI-TOF) and tandem mass spectrometry (MS/MS) using the SpOtOn Diagnostics Reagent Kit available in United Kingdom only.
Zentech company (Liège, Belgium) is developing a package for SCD newborn screening using MS/MS technology. The main objective of the present study will be to compare this new technique with the technique actually used in the hospital center of Lille (sub-contractor for SCD newborn screening of Lyon) and the haemoglobin analysis to test its accuracy (sensitivity and specificity).
Dr Céline RENOUX, MD, PhD | |
04.27.85.65.94 | |
[email protected] |
David CHEILLAN, MD, PhD | |
04 72 12 96 88 | |
[email protected] |
1 Day - 27 Days Years
Observational
All
Other
Infants with SCD newborn screening conducted in the hospital center of Lyon
Insufficient quantity of sampling
Parents’ opposition to their newborn’s participation in the study