Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Biomarkers and Chest Imaging


1 United States site


10 to 85 Years

Study type






About the study


Painful vasoocclusive crisis (VOC) occurs in people with sickle cell disease (SCD). People
with VOC have many visits to the hospital. About 10 30 percent of these people will go on to
develop acute chest syndrome (ACS). ACS can cause further ill health. It can also cause
death. Researchers want to find ways to diagnose ACS more quickly. To do this, they want to
use stored blood samples and scans from a study (the DeNOVO trial) that was closed in 2015.
They want to see if scans and samples taken of people with VOC who later developed ACS could
help diagnose ACS faster. The data of people in the DeNOVO study who did not develop ACS will
serve as controls.


To look at data from the DeNOVO trial to find a way to diagnose ACS more quickly.


People 10 85 years old who took part in NHLBI Protocol number 05-H-0019 (the DeNOVO trial).
The trial lasted from 2004 to 2008. The study was closed in November 2015.


Scans and intact, frozen samples from a study that was closed in 2015 will be studied. No new
participants will be enrolled.


– Patients (aged 10 years and older) presenting with vaso-occlusive crisis requiring
admission that were enrolled in the DeNOVO study specifically at the NIH clinical
center (n=65).We will use stored blood

samples and review radiological images from these patients.


  • Bethesda, Maryland, United States, National Heart, Lung and Blood Institute (NHLBI), 20892