Effects of Obstructive Sleep Apnea on the Frequency of Vaso-occlusive Crises Events and Bio-physical Markers in Sickle Cell Disease

Study point of contact

Emeric Stauffer, MD
+33 4 26 10 92 67
[email protected]

Locations

3 France sites

Age

15 to 50 Years

Phase

N/A

Study type

Interventional

Gender

All

Interventions

Diagnostic Test

Biological

Other

Compensation

Unknown

About the study

Despite the fact that obstructive sleep apnoea (OSA) is highly prevalent in the sickle cell
population, studies focusing on the associations of the two diseases and their common
pathophysiological mechanisms are scarce. OSA is one of the most common conditions
responsible for hemoglobin desaturation. The nocturnal hemoglobin desaturation occurring in
some sickle cell disease (SCD) patients with OSA could trigger hemoglobin S polymerization
and red blood cell (RBC) sickling, leading to further blood rheological alterations, hence
increasing the risks for VOC. Moreover, OSA has been demonstrated to increase oxidative
stress and inflammation in non Sickle Cell Disease (SCD) patients, which, in SCD patients,
could increase the risk for complications. Finally, OSA is accompanied by impaired vascular
function and autonomic nervous system dysfunction in the general population. Indeed, the
presence of OSA in SCD could increase the clinical severity of patients and the frequency of
VOC.

participation requirements

– Homozygous HbS (Hemoglobin S) (SS) patients,

– aged between 15 and 3 months and 50 years old,

– in steady state (i.e. without vaso-occlusive crisis or recent blood transfusion),

– followed by the sickle cell center of the Hospices Civils de Lyon,

– and showing symptoms of OSA.

participation restrictions

– Patients receiving treatment of OSA,

– recent blood transfusion (less than 2 months),

– patients not at steady state (VOC or acute chest syndrome less than 2 months),

– pregnancy.

Locations

  • Lyon, France, Hôpital Edouard Herriot, 69003 [Recruiting]
  • Lyon, France, Centre Léon Berard, 69008 [Recruiting]
  • Lyon, France, Hôpital de la Croix Rousse, 69317 [Recruiting]