Efficacy and Safety of Autologous Bone Marrow Stem Cells Infusion for Treatment of Chronic Leg Ulcer in Sickle Cell Disease Patients

Age

18 to 55 Years

Phase

Phase 1

Study type

Interventional

Gender

All

Interventions

Biological

Compensation

Unknown

About the study

The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow
stem cell implantation for the treatment of leg ulcer in adult patients with sickle cell
disease.

participation requirements

– Stable sickle cell disease patients

– Patient hospitalized into the dermatology unit

– Patient with an evolutive leg ulcer since more than 1 year

– No infection at the time of surgery

– Patient competent to give informed consent

participation restrictions

– Patients with a history of corticosteroids or on active therapy

– infection at the limb affected by ulcer

– Recurrent painful crises,

– Immunosuppressive drug therapy,

– Pregnancy,

– Presence of neoplastic disease or any other clinical concurrent condition other than
sickle cell disease that predisposed them to the development of leg ulcer