18 to 55 Years
Phase 1
Interventional
All
Biological
Unknown
The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow
stem cell implantation for the treatment of leg ulcer in adult patients with sickle cell
disease.
– Stable sickle cell disease patients
– Patient hospitalized into the dermatology unit
– Patient with an evolutive leg ulcer since more than 1 year
– No infection at the time of surgery
– Patient competent to give informed consent
– Patients with a history of corticosteroids or on active therapy
– infection at the limb affected by ulcer
– Recurrent painful crises,
– Immunosuppressive drug therapy,
– Pregnancy,
– Presence of neoplastic disease or any other clinical concurrent condition other than
sickle cell disease that predisposed them to the development of leg ulcer