Exercise Collapse Associated with Sickle Cell Trait (ECAST)
What is this?
The Sickle Cell 101 research team in collaboration with study investigator have reviewed this information to ensure it is patient-friendly and accurate.
About the Study
This study aims to understand why some SCT carriers are at higher risk for Exercise Collapse Associated with Sickle Cell Trait (ECAST). ECAST is a rare condition that can occur during exercise in individuals with sickle cell trait (SCT). It is characterized by:
Significantly greater effort during exercise than normal
Unusual muscle weakness and pain, commonly in the legs and lower back
Normal to modest temperature elevation while initially responsive
This study will enroll 30 African American men and women, aged 18-45, including both active duty and civilian individuals, who have SCT. Half of them will have a history of exercise collapse, while the other half will not. Participants will provide a blood sample and complete a questionnaire about their background and health. The blood samples will be used for various tests to identify specific substances related to ECAST and may also help predict the risk of ECAST in SCT carriers before an event occurs.
This study’s findings will help improve treatment and policies for both civilian and military populations affected by ECAST.