Glucose Metabolism in Sickle Cell Disease

Locations

1 United States site

Age

> 18 Years

Genotypes

SS

Study type

Observational

Gender

All

Compensation

Unknown

About the study

The purpose of the study is to better understand how the body handles sugars glucose and
fats, such as cholesterol and triglycerides in sickle cell disease, and what puts certain
persons at risk to develop diabetes. This understanding may help us to find new treatments to
control blood sugar and prevent diabetes in people with and without sickle cell disease
(SCD).

In this research, DNA and RNA will be isolated from blood cells. DNA will be used to find
genes that cause or protect from diabetes, high cholesterol and high triglyceride, and RNA
will be used for studies designed to find out how genes are doing their job of eventually
producing proteins.

participation requirements

– Major sickling genotype (hemoglobin SS, Sbeta0-thalassemia, SOarab, SDpunjab)

– Age >35 years

– BMI <25 kg/m2 or >26 kg/m2

– Steady state, defined as >two weeks from a hospitalization for vaso-occlusive crisis,
infection or surgery and not requiring immediate parenteral medication for pain
control

– Fasting state (>8 hours since ingesting food or medication for diabetes)

participation restrictions

– Patients receiving insulin therapy

– Acute inflammatory or infectious illness or injury

Locations

  • Chicago, Illinois, United States, University of Illinois at Chicago, 60612