| Louise Boyer-Chatenet, MS | |
| +33156093656 | |
| [email protected] |
| Brigitte Ranque, MD PhD | |
| [email protected] |
The CADRE study is a multinational observational cohort of patients with sickle-cell disease
(SCD) in five west and central sub-Saharan African countries. The aim of this project is to
describe the incidence and assess the predictive factors of SCD-related micro- and
macro-vascular complications in sub-Saharan Africa.
– age: five-year-old or more
– signature of informed consent Patients : major sickle cell syndrome confirmed by
hemoglobin phenotyping: SS, SC, SBeta+ or Sbeta0 Controls : healthy parents or
siblings of the patients, hospital staff or their children, matched on age+/- 3 years
and country (1 control for 4 patients)
unstable clinical status such as:
– vaso-occlusive crisis in the previous 15 days
– fever or infectious disease in the previous 15 days
– transfusion in the previous 2 months