|Jeffrey Glassberg, MD|
|Cindy Clesca, BA|
2 United States sites
> 18 Years
Participants age 18 and older with severe SCD phenotypes (Hb SS and Sβthalassemia0):
Do not have asthma (see
Not currently having a painful crisis (as defined by validated pain diary questions)
Do not have acute respiratory symptoms
Report of recent ECW (answers “Yes” to any question in Box 1)
Participant is already medically optimized (i.e. already on maximum dose hydroxyurea unless contraindicated and not undergoing medication titration).
Participant screens positive for possible undiagnosed asthma (Box 2)
Pregnant or planning to become pregnant
> 15 ED visits for SCD pain over the previous 12 months (due to concern for multi-factorial pain that may be less responsive to SCD therapies)
Have been discharged from the hospital within the previous 7 days.