Is the Preoperative Preparation of Sickle Cell Patients Optimal: Retrospective Assessment of Practices and Post-operative Complications in a Cohort of Children Followed at Hôpital Universitaire Des Enfants Reine Fabiola (HUDERF) and Who Have Been Managed According Local Guidelines Including Transfusion or Exchange Transfusion Before Surgery


1 Belgium site


< 18 Years

Study type






About the study

Children with sickle cell disease systematically receive a transfusion 2 to 5 days before
scheduled surgery (with the exception of minor surgeries) in order to avoid post-operative
complications of which the vaso-occlusive crisis and acute thoracic syndrome are the most

This standardized preoperative protocol was established on the basis of the results of
large-scale randomized studies, most of which date back over ten years, and which have
demonstrated the beneficial effects of transfusion (or transfusion exchange) preoperatively.
To date, several other more recent studies (but not controlled) have questioned this type of
systematic management.

The purpose of this study is to review retrospectively data of sickle cell children who have
undergone elective surgery at the Huderf in the last ten years and to identify the eventual
complications encountered. The most common procedures in these patients are: tonsillectomy
with or without associated adenoids, splenectomy and cholecystectomy.

General data on sickle cell disease (history, genotype, G6PD deficiency, biology and previous
complications), pre-surgical preparation, surgery and post surgical management and
complications will be collected and analyzed.

This retrospective analysis will allow an objective assessment of the current quality of care
and will provide useful data to improve patient management.

participation requirements

– Sickle cell disease with surgery during the 2010-2019 period

participation restrictions

– None


  • Brussels, Brussles, Belgium, Hôpital Universitaire Des Enfants Reine Fabiola, 1020