About the study
Children with sickle cell disease systematically receive a transfusion 2 to 5 days before
scheduled surgery (with the exception of minor surgeries) in order to avoid post-operative
complications of which the vaso-occlusive crisis and acute thoracic syndrome are the most
This standardized preoperative protocol was established on the basis of the results of
large-scale randomized studies, most of which date back over ten years, and which have
demonstrated the beneficial effects of transfusion (or transfusion exchange) preoperatively.
To date, several other more recent studies (but not controlled) have questioned this type of
The purpose of this study is to review retrospectively data of sickle cell children who have
undergone elective surgery at the Huderf in the last ten years and to identify the eventual
complications encountered. The most common procedures in these patients are: tonsillectomy
with or without associated adenoids, splenectomy and cholecystectomy.
General data on sickle cell disease (history, genotype, G6PD deficiency, biology and previous
complications), pre-surgical preparation, surgery and post surgical management and
complications will be collected and analyzed.
This retrospective analysis will allow an objective assessment of the current quality of care
and will provide useful data to improve patient management.
– Sickle cell disease with surgery during the 2010-2019 period