Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia

Study point of contact

Jaclyn Janoski, BS, MS, CCRP
312-227-4825
[email protected]
Devin S Muntz, BA
312-227-4824
[email protected]

Locations

1 United States site

Age

8 to 21 Years

Genotypes

SS

Study type

Observational

Gender

All

Compensation

Unknown

About the study

The purpose of this study is to use comprehensive exercise testing to examine longitudinal
changes in exercise capacity over a 2 year period in children and young adults with sickle
cell anemia.

participation requirements

1. age 8 to 21 years old; AND

2. Hb SS or S-β0 thalassemia disease, confirmed by hemoglobin analysis; AND

3. Previously participated in ClinicalTrials.gov ID: NCT01527799

participation restrictions

1. inability to perform maximal testing due to physical limitation (e.g. stroke or
avascular necrosis); OR

2. history of exercise-induced syncope or arrhythmias. Subjects will wait at least 2
weeks following any vaso-occlusive pain episode and 12 weeks following any
disease-related complication requiring transfusion support. Individuals on hydroxyurea
will be eligible. A total of 30 controls without SCA or sickle cell trait will be
matched for age, sex and race and recruited from the siblings, friends or relatives of
subjects enrolled on this study

Locations

  • Chicago, Illinois, United States, Ann & Robert H. Lurie Children's Hospital of Chicago, 60611 [Recruiting]