Management of Severe Acute Malnutrition in Children With Sickle Cell Disease Greater Than 5 Years of Age Living in Northern Nigeria

About the study

Except for children with HIV, all recommendations for treatment of childhood malnutrition are for children 5 years of age agree to participate over a 12-week period. The investigators will also establish a safety protocol for monitoring potential complications associated with treating severe malnutrition in children > 5 years of age with and without SCA, in a low-resource setting.

Study point of contact

Leshana Saint Jean, PhD
[email protected]
Michael DeBaun, MD, MPH
615-875-3040
[email protected]

Locations

2 Nigeria sites

1 United States site

Age

5 to 12 Years

Genotypes

SCA

Phase

Phase 2

Study type

Interventional

Age

5 Years - 12 Years

Gender

All

Interventions

Drug

Dietary Supplement

Compensation

Unknown

participation requirements

confirmed diagnoses of SCA, comparison children without SCD
severe malnutrition defined as a BMI z-score < -3 age between 5 and 12 years (assessment can take place up until the 13th birthday) pass the appetite test uncomplicated malnutrition (good appetite, alert, no signs of infection of respiratory distress)

participation restrictions

children with complicated severe acute malnutrition
children with electrolyte disturbances (serum Na, K, Ca, PO4) at baseline
children on disease-modifying therapy (hydroxyurea or regular blood transfusion therapy)
children enrolled in other studies
children with diabetes and other chronic illnesses
children with known HIV infection
children with a known allergy to dairy or peanuts.

Locations

  • Nashville, Tennessee, United States, Vanderbilt University Medical Center, 37232-9000 [Active, not recruiting]
  • Kano, Nigeria, Aminu Kano Teaching Hospital [Recruiting]
  • Kano, Nigeria, Murtala Mohammad Specialist Hospital [Recruiting]
Last updated 2021-12-08