Management of Severe Acute Malnutrition in Children With Sickle Cell Disease Greater Than 5 Years of Age Living in Northern Nigeria

Study point of contact

Djamila Ghafuri
[email protected]
Michael DeBaun, MD, MPH
615-875-3040
[email protected]

Locations

3 Nigeria sites

1 United States site

Age

5 to 12 Years

Phase

Phase 2

Study type

Interventional

Gender

All

Interventions

Drug

Dietary Supplement

Compensation

Unknown

About the study

Except for children with HIV, all recommendations for treatment of childhood malnutrition are
for children
5 years of age agree to participate over a 12-week period. The investigators will also
establish a safety protocol for monitoring potential complications associated with treating
severe malnutrition in children > 5 years of age with and without SCA, in a low-resource
setting.

participation requirements

– confirmed diagnoses of SCA, comparison children without SCD

– severe malnutrition defined as a BMI z-score < -3 - age between 5 and 12 years (assessment can take place up until the 13th birthday) - pass the appetite test - uncomplicated malnutrition (good appetite, alert, no signs of infection of respiratory distress)

participation restrictions

– complicated malnutrition (poor appetite, altered mental status, severe bilateral
edema, infections, dehydration, sepsis or respiratory distress)

– unable to swallow

Locations

  • Nashville, Tennessee, United States, Vanderbilt University Medical Center, 37232-9000
  • Kano, Nigeria, Aminu Kano Teaching Hospital, P.MB. 3452
  • Kano, Nigeria, Aminu Kano Teaching Hospital
  • Kano, Nigeria, Murtala Mohammad Specialist Hospital