Obesity in Pediatric Sickle Cell Disease: A New Phenomenon

About the study

The objective of this project is to determine the prevalence of hypertension, hyperlipidemia
and hyperglycemia in the pediatric population with sickle cell disease who are obese in
Mississippi compared to those pediatric patients with sickle cell disease who are not
overweight/obese. The pediatric hematology department at the University of Mississippi
Medical Center (UMMC) has a relatively large population of patients with sickle cell disease
who are overweight and obese. This is a paradoxical trend since high-energy expenditure of
the body to produce new red blood cells usually results in underweight to normal weight
patients. From our previous chart review, the investigators found our pediatric patients with
sickle cell disease to have similar rates of overweight and obesity to that of state and
national levels. The metrics our team will measure include: blood pressure, blood cholesterol
levels and blood glucose levels. The investigators expect to find higher rates of
hypertension, high cholesterol and high glucose levels in the overweight and obese patients
with SCD compared to that of underweight and normal weight. Our ultimate goal for follow up
projects will be to determine the baseline risk of hypertension, hyperlipidemia and
hyperglycemia in this population so we can then determine effective, sustainable
interventions for weight and the co-morbidities that come with increasing weight status. Our
goal would also be to educate the patient and families on these interventions and provide
them with resources, which could lead to an overall improvement in health and patients
quality of life.

Study point of contact

Erin Jackson, MD
[email protected]


1 United States site


10 to 19 Years



Study type






participation requirements

– 10-19 years

– diagnosed with SCD genotype HbSS, HbSβ0, HbSC, or HbSβ+

– regularly followed by the UMMC Pediatric SCD clinic (i.e., average visit at least once
per year in past two years)

participation restrictions

– non-English speaking

– patient in acute vaso-occlusive pain crisis (which can increase blood pressure)

– cognitive or developmental delays that preclude ability to complete study


  • Jackson, Mississippi, United States, University of Mississippi Medical Center, 39216 [Recruiting]
Last updated 2021-04-28