Sickle cell anemia (SCA) is one of the most neglected diseases worldwide, according to the
World Health Organization. In the adult population with SCA, the systemic effects of the
disease, such as respiratory and peripheral muscle dysfunction, cause a decrease in quality
of life. As a consequence, there is a concern about functional rehabilitation, since the
aging of this population is already a reality in our environment. Thus, the objective of this
project is to evaluate the effects of functional rehabilitation on quality of life in adult
patients over 18 years of SCA. In this longitudinal intervention study, patients will be
submitted to a three-month rehabilitation program. Before and after the intervention,
patients will be submitted to the following assessments: spirometry; quality of life
questionnaire – Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36); functional
scale of joint integrity – Lower Extremity Functional Scale (LEFS); fatigue assessment scale
– Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); physical activity
assessment questionnaire – International Physical Activity Questionaire (IPAQ); peripheral
muscle assessment (handgrip and isometric dynamometry of the quadriceps muscle); and 6-minute
walk test (6MWT). The protocol will consist of warm-up and cool-down exercises, muscle
strengthening and endurance exercises, aerobic training, balance training and proprioception.
Thus, it is expected that patients with sickle cell anemia will benefit significantly, with a
consequent improvement in musculoskeletal function, pain and health-related quality of life.
– Patients with sickle cell anemia, of both sexes, aged ≥ 18 years.
– Patients who have clinical stability and are eligible for the treatment protocol.
– Presence of comorbidities not related to sickle cell anemia.
– Patients with inability to perform the six-minute walk test.
– Patients who have cognitive impairment that impairs their inclusion in the study.
– Abandonment of treatment during the application of the protocol.
– Uncontrolled hypertension or use of psychotropic drugs.
– Any significant limitations due to osteoarthropathy.
– Have had any orthopedic surgery in the previous year.
Rio de Janeiro, Brazil, Agnaldo José Lopes, 22745-271 [Recruiting]