Population Pharmacokinetics (PK) of Melphalan in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation (HCT)

About the study

Melphalan is a chemotherapy drug used extensively in bone marrow transplantation. The goal of
this study is to determine what causes some children to have different drug concentrations of
melphalan in their bodies and if drug levels are related to whether or not a child
experiences severe side-effects during their bone marrow transplant. The hypothesis is that
certain clinical and individual factors cause changes in melphalan drug levels in pediatric
bone marrow transplant patients and that high levels may cause severe side-effects.