Prevention Of Morbidity In Sickle Cell Disease Pilot Phase

Study point of contact

Fenella Kirkham, Dr
[email protected]

Locations

2 United Kingdom sites

Age

4 to 16 Years

Genotypes

SS

Phase

Phase 2

Study type

Interventional

Gender

All

Interventions

Device

Compensation

Unknown

About the study

The hypothesis is that in sickle cell anaemia, nocturnal oxyhaemoglobin desaturation, is
associated with low processing speed index, and this morbidity can be reduced with overnight
auto Continuous Positive Airways Pressure and/or oxygen supplementation.

participation requirements

1. Age >4 years.

2. Informed consent with assent in accordance with UK ethical committee(COREC) system
must be signed by the patient’s parent or legally authorized guardian acknowledging
written consent to join the study. When suitable, patients will be requested to give
their assent to join the study.

3. Haemoglobin SS (homozygous sickle cell anaemia) diagnosed by standard techniques.
Participating institutions must submit documentation of the diagnostic haemoglobin
analysis.

Locations

  • London, United Kingdom, Neuroscience Unit, Institute of Child Health, WC1N 1EH [Recruiting]
  • London, United Kingdom, Kings College hospital, WC2R 2LS [Recruiting]