Red Blood Cell – IMProving trAnsfusions for Chronically Transfused Recipients (RBC-IMPACT)

(Aim #1):

Well-characterized transfusion-dependent form of SCD or thalassemia (including Hemoglobin E-thalassemia and sickle-beta thalassemia) on chronic simple transfusion therapy
On a regular simple RBC transfusion schedule (i.e., 1-3 units scheduled every 2-6 weeks and on a minimum 6-month chronic transfusion trial)
Seen at any participating domestic hub hospital (i.e., Columbia University Irving Medical Center/Morgan Stanley Children’s Hospital of New York, Weill Cornell Medical Center/Komansky Children’s Hospital, Boston Children’s Hospital, Froedtert & Medical College of Wisconsin/Children’s Wisconsin, University of California San Francisco, Benioff Children’s Hospital Oakland) or enrolled in the Brazil REDS-IV-P sickle cell disease cohort and seen at any participating Brazil hemocenter (i.e., Childrens Institute and Adult Clinics at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo – HCFMUSP, HEMOAM – Amazonas, HEMOMINAS – Minas Gerais, HEMOPE -Pernambuco, and HEMORIO – Rio de Janeiro)