Red Blood Cell Survival Study: The Impact of Oxidative Stress on Erythrocyte Bilogy

Study point of contact

Sarah Beggi
414-937-6833
[email protected]
Matt Karafin, MD, MS
414-937-6833
[email protected]

Locations

1 United States site

Age

18 to 60 Years

Phase

Phase 2

Study type

Interventional

Gender

All

Interventions

Biological

Compensation

Unknown

About the study

This study will address if red blood cells transfused to a sickle cell patient from a donor
with a G6DP enzyme deficiency have a different lifespan as measured by the percentage of red
blood cells that survive post-transfusion compared to red blood cells transfused to a sickle
cell patient from a donor without a G6DP enzyme deficiency.

participation requirements

1. Age 18-60 years

2. HbSS/HbSβ0-thalassemia

3. Stead state (no pain or baseline pain and ≥1 month from any hospital admission)

4. Received ≥1 RBC transfusion in the past 2 years, but none in the past 120 days.

participation restrictions

1. Currently on a chronic transfusion program

2. History of transfusion reactions not adequately managed by antihistamines

3. ≥2 alloantibodies or warm autoantibodies

4. Known G6PD deficiency

5. Known iron overload (ferritin >2000)

6. Hepato- or splenomegaly

7. Participation in another therapeutic trial

8. Pregnant or nursing

9. HIV positive

10. At investigator discretion for uncontrolled inter-current illness or social situation
limiting compliance with study requirements.

11. Inability to speak and/or read English

Locations

  • Milwaukee, Wisconsin, United States, Medical College of Wisconsin and Froedtert Hospital, 53226