Safety and Efficacy of Glutamine in Preventing Vaso-occlusive Crisis Among Sickle Cell Disease Patients: Randomized Controlled Study

About the study

Prospective phase IV interventional open label randomized controlled trial to assess safety and efficacy of glutamine in preventing vaso-occlusive crisis (VOC) episodes in sickle cell pediatrics and adolescents’ patients

Study point of contact

Fatma SE Ebeid, MD
+201095569596
[email protected]

Locations

110 Egypt sites

Age

2 Years - 18 Years

Phase

Phase 4

Study type

Interventional

Gender

All

Interventions

Drug

Other

participation requirements

Children and adolescents diagnosed with sickle cell disease by haemoglobin electrophoresis and had at least two pain crises (no upper limit) documented during the previous year; a pain crisis is defined as pain leading to treatment with a parenteral administered narcotic or ketolac in an emergency department (ED) (or outpatient treatment centre) or during hospitalization.

Patients receiving hydroxyurea at a fixed dose for at least 3 months before screening.

participation restrictions

Patients with sickle cell trait and other hemoglobinopathy.

–

Locations

  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]
  • Cairo, Non-US, Egypt, Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center [Recruiting]
  • Cairo, Egypt, Ain Shams University [Recruiting]

MORE INFORMATION

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Last updated 2022-05-07