Sickle Cell Anemia – A Comparative Study Between Three Ethnical Communities, a Multicenter Study. Clinical and Genetic Characteristics of Sickle Cell Anemia (SCA) Patients in Three Different Communities.


3 Israel sites

1 United States site


1 to 40 Years

Study type






About the study

The purpose of this study is to take advance of the presence of two different cohorts of SCA
patients in one country, the first group included SCA patients from Bedouin Arab origin that
lives in Israel for more than one century and originally comes from African countries or
Saudi Arabia, those patients lives in north east Israel and are treated at the Hematology
Unit of the Emek Medical Center, the second group are SCA patients from African origin that
come to Israel in the last decades and belong to original African population, this group
receive treatment at the Pediatric Hematology Unit, Dana Children’s Hospital, Ichilov Medical
Center. A third group is a cohort of SCA patients treated at Schneider Children’s Hospital
Hematology Unit. Those patients belong also to the Israel Arab population and patients from a
village that African Muslims live for many years. The characteristics of the three groups
will be compared to the characteristics of a fourth group, a cohort of Afro-American SCA
patients that are followed up and treated at the Pediatric Hematology Unit, Detroit
Children’s Medical Center, Detroit, Michigan, USA.

participation requirements

– All patients followed up in the centers that participate in the study.

– Pregnancy will not be considered as

participation restrictions


Exclusion Criteria:

– Patients with SC and SD disease will not be included.


  • Detroit, Michigan, United States, Children's Hospital of Michigan, Detroit Medical Center - Wayne State University
  • Afula, Israel, Pediatric Hematology Unit HaEmek Medical Center, 18101
  • Petah Tikva, Israel, Pediatric Hematology Unit - Schneider Children's Hospital - Beilinson Medical Center
  • Tel Aviv, Israel, Pediatric Hematology Unit - Dana Children's Hospital - Ichilov Medical Center