| Anoosha Habibi, MD | |
| (0)1 49 81 27 73 ext +33 | |
| [email protected] |
| Serge Adnot, MD. PhD | |
| (0)1 49 81 26 90 ext +33 | |
| [email protected] |
1 France site
> 18 Years
N/A
Interventional
All
Other
Unknown
Hypothesis is that the occurrence of nocturnal Vaso-Occlusive Crisis (VOC) and priapism in
adults might be related to episodes of nocturnal desaturation secondary to a sleep apnea
syndrome. Investigator hypothesize that chronic biological consequences of Obstructive Sleep
Apnea (hypercoagulability, endothelial dysfunction …) favour VOC and acute manifestations
(nocturnal desaturation) favour nocturnal VOC.
The confirmation of this hypothesis will lead investigator to propose a systematic screening
of obstructive sleep apnea (OSA) in patients with nocturnal VOC. Moreover, systematic
treatment of OSA in sickle cell patients could help significantly reduce the number and
severity of nocturnal VOC.
Night VOC Group:
– night VOC ≥ 2 in the previous year
– written informed consent
Daytime VOC Group:
– VOC no nocturnal
– diurnal VOC ≥ 2 in the previous year
– written informed consent
Slightly symptomatic group:
– no hospitalization for VOC
– written informed consent
– Taking opioids
– Taking medication that alters sleep (antidepressants, benzodiazepines …)
– Known history of sleep apnea syndrome
– Known history of serious psychiatric disorder
– Recent vaso-occlusive crisis (within 3 weeks)
– Changes in background treatment (Hydrea or exchange transfusions) in the past 12
months