Clinical Trials

Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.

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A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Voxelotor (GBT440) in Pediatric Participants With Sickle Cell Disease

This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.

Locations

16 United States sites

5 Nigeria sites

4 Egypt sites

3 Italy sites

3 Kenya sites

3 United Kingdom sites

2 Oman sites

2 Ghana sites

2 Saudi Arabia sites

Age

2 to 14 Years

Phase

Phase 3

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Follow-up of Phase 1/2 Study of CaspaCIDe T Cells (BPX-501) From an HLA-partially Matched Family Donor After Negative Selection of TCR αβ+T Cells in Pediatric Patients Affected by Hematological Disorders

This is a long-term follow up study evaluating the safety of BPX-501 T cells (rivogenlecleucel) and infused in pediatric patients previously enrolled on the BP-004 study.

Locations

1 Italy site

1 Saudi Arabia site

Age

1 to 18 Years

Phase

Phase 1/Phase 2

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Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients: Prospective Randomized Control Trial

Investigators hypothesize that administration of ketamine for pain relief in sickle cell patients with vaso-occlusive crisis early on will lead to a more rapid improvement in pain score and less narcotic requirement.

Locations

1 Saudi Arabia site

Age

18 to 60 Years

Phase

N/A

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HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen

Sickle cell disease (SCD) is the most common inherited blood disorder in Saudi Arabia .

Locations

1 Saudi Arabia site

Age

3 to 18 Years

Genotypes

HbSS

Phase

Phase 2

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Long-term Safety and Efficacy Study of Ferriprox® for the Treatment of Transfusional Iron Overload in Patients With Sickle Cell Disease or Other Anemias

This is a long-term follow-up to an earlier study, LA38-0411.

Locations

5 United States sites

4 Egypt sites

2 United Kingdom sites

1 Canada site

1 Saudi Arabia site

Age

> 3 Years

Phase

Phase 4

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The Efficacy and Safety of Ferriprox® for the Treatment of Transfusional Iron Overload in Patients With Sickle Cell Disease or Other Anemias

This research is being done so that we can look at the safety and efficacy of deferiprone in people with sickle cell disease or other anemias.

Locations

9 United States sites

8 Egypt sites

5 Brazil sites

4 United Kingdom sites

3 Saudi Arabia sites

3 Tunisia sites

3 Turkey sites

1 Canada site

1 Qatar site

Age

> 2 Years

Phase

Phase 4

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Diastolic Dysfunction in Sickle Cell Disease During Vaso-occlusive Crisis

This study is designed to investigate the presence and absence of abnormal heart muscle contractions during sickle cell crises.

Locations

1 Saudi Arabia site

Age

> 14 Years

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