This will be a descriptive cohort study of intranasal ketamine as the initial analgesic for children with sickle cell disease who present to the pediatric emergency department with vaso-occlusive crisis and are awaiting intravenous line placement.
116 United States sites
3 Years - 25 Years
Phase 3
Interventional
All
Drug
History of Hemoglobin SS or SC disease
Age 3 years old to 25 years old presenting to the PED with vaso-occlusive with moderate-severe pain determined at triage as pain score (FACES or numeric rating scale) ≥ 5
Parent or patient willing to provide consent/assent
English speaking
Patient with concern for more severe complications including acute chest, splenic sequestration, sepsis, stroke, non-VOC pain, asthma exacerbation
Allergy to ketamine
GCS<15
Obstructive nasal anatomy as per parent history
History of a psychiatric disorder
Pregnant patients will be excluded. Female patients > 12 years old are routinely tested for pregnancy in our PED. Patients found to be pregnant will not be enrolled in study.