Transcranial Direct Current Stimulation Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease

About the study

So far, no study investigated the safety and efficacy analgesic of transcranial direct current stimulation (tDCS) associated to peripheral electrical stimulation (PES) in individuals with SCD who suffer from chronic pain. Several studies have reported a decrease in O²Hb concentration in the regions below the electrodes and in other cortical areas during anodic or cathodic tDCS, which implies a risk factor for vasoocclusive events in individuals with SDC due to polymerization of hemoglobin when exposed to these low O²Hb concentrations. For this reasion, the aim main of this study is to assess the effect of a single session of transcranial direct current stimulation (tDCS) associated to peripheral electrical stimulation (PES) on safety and efficacy analgesic in individuals with sickle cell disease (SCD). Others aims sencondaries are evaluate the effect of a single session of transcranial direct current stimulation (tDCS) associated to peripheral electrical stimulation (PES) on biomarkers neurophysiological and inflammatory.

Study point of contact

Tiago S. Lopes, Sr
55 75 99963-6349
[email protected]
Abrahão F Baptista, Prof.
55 11 98830-3941
[email protected]

Locations

1 Brazil site

Age

18 to 50 Years

Phase

Phase 2

Study type

Interventional

Age

18 Years - 50 Years

Gender

All

Interventions

Device

Compensation

Unknown

participation requirements

Being diagnosed with sickle cell disease hemoglobin electrophoresis.
Be aged 18 years old to 50 years old.
Having signed the consent form and clarified.
Having chronic pain with at least 3 months duration.
Being diagnosed with femoral head osteonecrosis
Have more than one type of chronic pain.

participation restrictions

Have cochlear implants, pacemakers or metallic implant in the skull / brain;
Have metallic implant application site of peripheral stimulation;
History of head trauma;
Pregnancy;
seizures or epilepsy History;
Being in drug use that modify neuronal activation threshold (eg antidepressants and anticonvulsants);
Having diagnosis of fibromyalgia, or any impairment to be confused with the symptoms of SCD;
Have pain confirmed neuropathic type.

Locations

  • Salvador, Bahia, Brazil, Functional Electrical Stimulation Laboratory, 40110-902 [Recruiting]
Last updated 2018-09-21