Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease

Age

18 to 55 Years

Phase

Phase 1/Phase 2

Study type

Interventional

Gender

All

Interventions

Procedure

Compensation

Unknown

About the study

The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow
stem cells in sickle cell disease patients with osteonecrosis

participation requirements

– Stable sickle cell disease patients

– FICAT classification of osteonecrosis, inclusive of Stage II.

– Diagnosis will be based on X-Ray and magnetic resonance imaging (MRI).

– No infection in affected bones at the time of surgery.

– Patient competent to give informed consent.

– Scoring at least 20 points on the pain and daily life activities questionnaire.

participation restrictions

– FICAT stage III or more

– Patients with a history of corticosteroids or on active therapy

– Bone infection at the limb affected by necrosis

– Recurrent painful crises,

– Immunosuppressive drug therapy,

– Pregnancy,

– Presence of neoplastic disease or any other clinical concurrent condition other than
sickle cell disease that predisposed them to the development of osteonecrosis of the
femoral head