A Phase 3 Study to Evaluate the Safety and Efficacy of a Single Dose of CTX001 in Pediatric Subjects With Severe Sickle Cell Disease

About the study

This is a single-dose, open-label study in pediatric participants with severe SCD and hydroxyurea (HU) failure or intolerance. The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (CTX001).

Study point of contact

Medical Information
617-341-6777
[email protected]

Locations

128 United States sites

41 Italy site

36 United Kingdom sites

25 Germany sites

Age

2 Years - 11 Years

Phase

Phase 3

Study type

Interventional

Gender

All

Interventions

Biological

participation requirements

Diagnosis of severe SCD as defined by:

Documented SCD genotypes
History of at least two severe VOCs events per year for the previous two years prior to enrollment
Hydroxyurea (HU) failure unless HU intolerant
Eligible for autologous stem cell transplant as per investigators judgment

Key

participation restrictions

A willing and healthy 10/10 human leukocyte antigen (HLA)-matched related donor
Prior hematopoietic stem cell transplant (HSCT).
Clinically significant and active bacterial, viral, fungal, or parasitic infection

Other protocol defined Inclusion/Exclusion criteria may apply.

Locations

  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Charlotte, North Carolina, United States, Atrium Health Levine Children's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Charlotte, North Carolina, United States, Atrium Health Levine Children's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Charlotte, North Carolina, United States, Atrium Health Levine Children's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Charlotte, North Carolina, United States, Atrium Health Levine Children's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]
  • Charlotte, North Carolina, United States, Atrium Health Levine Children's Hospital [Recruiting]
  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia [Active, not recruiting]
  • Memphis, Tennessee, United States, St. Jude Children's Research Hospital [Active, not recruiting]
  • Nashville, Tennessee, United States, The Children's Hospital at TriStar Centennial Medical Center/ Sarah Cannon Center for Blood Cancers [Active, not recruiting]
  • Dusseldorf, Germany, University Hospital Duesseldorf - Department of Pediatric Oncology, Hematology and Clinical Immunology [Recruiting]
  • Rome, Italy, Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica Ospedale Pediatrico Bambino Gesu - IRCCS [Recruiting]
  • London, United Kingdom, St Mary's Hospital [Recruiting]

MORE INFORMATION

View on ClinicalTrials.gov
Enroll Now
Last updated 2023-08-28