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A Test of the Safety, Effectiveness, and Acceptability of an Improvised Dressing for Sickle Cell Leg Ulcers in a Tropical Climate

One in 300 Jamaicans have HbSS sickle cell disease, and of these, up to 70% will suffer from sickle cell leg ulcers (SCLUs).

Locations

1 Jamaica site

Age

13 to 70 Years

Genotypes

HbSS

Phase

N/A

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Reduced Intensity Related Donor Peripheral Blood Derived Hematopoietic Progenitor Cell Transplantation for Patients With Severe Sickle Cell Disease

This study is being done to test a transplant method that may have fewer side effects (or less toxic, less harmful) than conventional high dose chemotherapy conditioning-based transplants for children and young adults with Sickle Cell Disease (SCD).

Locations

1 United States site

Age

2 to 25 Years

Phase

Phase 2

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Designing an Implementation Strategy for Delivering Routine Mental Health Screening and Treatment for Adolescents and Adults With Sickle Cell Disease

African Americans living with chronic health conditions are more likely to experience depression and other mental health disorders than their healthy counterparts, and are more likely to experience severe depression than whites, but less likely to be diagnosed or receive treatment.

Locations

1 United States site

Age

16 to 30 Years

Phase

N/A

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Prevalence of Osteoporosis in Sickle Cell Disease

Sickle cell disease is the most common single-gene disease in the world.

Locations

1 France site

Age

20 to 40 Years

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A Longitudinal, Digital Study Using the Medication Adherence Reasons Scale (MAR-Scale) to Identify the Reasons for Non-adherence to Medications in Rare Disease

The purpose of this study is to use the Medication Adherence Reasons Scale (MAR-Scale) to determine the extent of non-adherence to specific medications indicated to treat cystic fibrosis, hemophilia (A or B), idiopathic pulmonary fibrosis, myasthenia gravis, and sickle cell disease, and to identify the top patient-reported reasons for non-adherence.

Age

> 18 Years

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Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia

The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients .

Locations

4 United States sites

Age

5 to 50 Years

Genotypes

HbSS

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The Role of Oxygen Reserve in Brain Growth and Cortical Thickness in Children With and Without Sickle Cell Anemia

The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life.

Age

4 to 21 Years

Phase

N/A

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A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects With Sickle Cell Disease

A Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease .

Locations

4 United States sites

Age

18 to 65 Years

Genotypes

HbSS

Phase

Phase 2

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Desmopressin as a Therapy for Nocturnal Enuresis in Pediatric Patients With Sickle Cell Disease

This study assesses if using the medication desmopressin will decrease nightime bedwetting in children with sickle cell disease.

Locations

1 United States site

Age

8 to 21 Years

Genotypes

SS, SC

Phase

Phase 4

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Single-arm Phase 2 Study of Oral Isoquercetin in Sickle Cell Disease

This research study is being done to assess the safety and effectiveness of isoquercetin to reduce levels of soluble P-Selectin in patients with sickle cell disease.

Locations

3 United States sites

Age

18 to 50 Years

Phase

Phase 2

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