Cerebral Oxygen Metabolism in Children

About the study

The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life.

We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain’s blood vessels expand and constrict to regulate blood flow based on the brain’s needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain’s blood flow changes in small ways during everyday activities, such as normal brain growth, exercise, or deep concentration. Significant illness or psychological stress may increase the brain’s metabolic demand or cause other bigger changes in blood flow. If blood vessels are not able to expand to give more blood flow when metabolic demand is high, the brain may not get all of the oxygen it needs. In extreme circumstances, if the brain is unable to get enough oxygen for a long time, a stroke may occur. Sometimes small strokes occur without other noticeable changes and are only detectable on an MRI. These are sometimes called “silent strokes.” In less extreme circumstances, not having as much oxygen as it wants may cause the brain to grow and develop more slowly than it should.

One way to test the ability of blood vessels to expand is by measuring blood flow while breathing in carbon dioxide. Carbon dioxide causes blood vessels in the brain to dilate without increasing brain metabolism.

During this study participants may be asked to undergo a blood draw, MRI, and potential neuropsychological assessments. It is also possible that the study team will use a special mask to control the amount of carbon dioxide the participants breathe in so they don’t breathe in too much.

Study point of contact

Contact Name:	Kristin Guilliams, MD
Phone:	3144546120
Email:	[email protected]

Locations

98 United States sites

Age

3 Years - 50 Years

Phase

Not Applicable

Study type

Interventional

Gender

All

Interventions

Other

Criteria

Healthy Controls:

Healthy controls ages 3-50 years of age
Able to participate in MRI scan without sedation
Not currently pregnant
No significant psychiatric history, defined as having a severe psychiatric diagnosis, per PI discretion
No history of epilepsy
No history of stroke or cerebrovascular disease
May have occasional headaches if not taking a daily preventative medication for headaches
Not on vasodilatory medication, such as sildenafil or verapamil

Sickle Cell Anemia Participants:

Ages 3-50 years of age
Hb SS or SBeta-thal
Able to participate in MRI scan without sedation
Not currently pregnant
Not on vasodilatory medication, such as sildenafil or verapamil

Extracorporeal Membrane Oxygenation (ECMO) Survivors:

Ages 3-50 years of age
History of cannulation for ECMO
Able to participate in MRI scan without sedation
Not currently pregnant
Not on vasodilatory medication, such as sildenafil or verapamil

Locations

Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]

Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]
Saint Louis, Missouri, United States, Washington University of St. Louis [Recruiting]

MORE INFORMATION

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Last updated 2023-01-27