|John F Tisdale, M.D.|
1 United States site
< 45 Years
Pregnant women who are at risk of having an infant with sickle cell anemia related
The types of sickle cell disease include the following:
– Hemoglobin S <=0 thalassemia - Hemoglobin S <=+ thalassemia - Hemoglobin SC - Hemoglobin SD - Hemoglobin SE - Hemoglobin SS - Maternal subjects must be between 18 and 45 years old. - Maternal subjects must be able to provide informed consent. - Maternal subjects deliver at INOVA Fairfax Hospital (insurance approval) - Maternal subjects enrolled on other studies are not excluded, unless the other study may interfere with the present one. - Maternal subjects in active labor will be enrolled at the discretion of her physician. (Note: in rare cases that a mother is identified as a potential candidate for the study during labor, it is at the discretion of her physician whether she could be in a condition to discuss about the study and provide informed consent (then IFH has to obtain the Informed Consent). After labor and delivery, the study will be discussed again with the mother.)
– The maternal subject will not be eligible for study if she is known to be positive for
one or more of the following diseases transmissible by blood: HIV, hepatitis B,
hepatitis C, or HTLV or ZIKV.
– Maternal subject will not be eligible for the study if she has active syphilis,
toxoplasmosis, malaria or babesia during pregnancy.
– Maternal subject will not be eligible for the study if the pregnancy resulted from egg
donation or sperm donation.
– Maternal subject is unable to give informed consent.
– Maternal subject is known to have a fetus with a significant congenital anomaly,
either not compatible with life, or requiring immediate surgical intervention or care
in the Neonatal Intensive Care Unit or.
– Maternal subject delivers at another facility, not INOVA Fairfax Hospital.
– Maternal subject has cancer or received treatment for cancer during pregnancy
– Maternal subject may be excluded at the time of delivery if the attending physician or
collection staff deems that the cord blood collection is inadvisable, due to
unanticipated obstetrical complications.