|Michel GALINSKI, Pr|
|5 56 79 48 26|
|Cedric GIL-JARDINE, Dr|
5 France sites
1 Guadeloupe site
1 French Guiana site
18 Years - 75 Years
Age 18 to 75 years old;
Signs of a vaso-occlusive crisis (migratory bone pain, which may occur in the limbs, spine, thorax, pelvis, skull) or crisis known as such by the patient;
Severe pain (NRS ≥ 6/10) on admission to the ED;
Registered with the social security scheme or his beneficiaries (except AME)
Signature of free and informed consen.
Strong opioids received in the previous 6 hours;
Pregnancy or breastfeeding;
Woman not menopausal nor sterile without effective contraception (HAS criteria)
Oxygen saturation below 93%;
Patients who cannot cooperate because of a State of agitation or a Cognitive impairment
Unable to communicate;
Unable to do self-assessment;
Allergy or intolerance to opiates or nitrous oxide.
Abuse or addiction to opioids
Severe asthma or chronic obstructive bronchopulmonary disease
Pulmonary disease necessitating oxygen
Presence of seriousness signs:
All respiratory seriousness signs
all neurologic signs or consciousness impairment (coma Glasgow scale under 15)
hyperthermia over than 39°C
Signs of intolerance of acute anemia
Signs of hemodynamic failure
Known organ failure (renal insufficiency, pulmonary high blood pressure)
A description by the patient of a non usual crisis.
Current treatment with nasal vasoconstrictors is ongoing
Head injury with suspicion of high intracranial pressure
Severe thoracic trauma or decompensated respiratory insufficiency
Contraindications of intranasal administration:
Nose or sinusal surgery in the previous 6 months before inclusion
Chronic nose and upper airway alteration (ex. facial malformation)
Acute nose and upper airway alteration (ex. Epistaxis, acute respiratory infection, sinusitis).
Contraindication to nitrous oxide
Contraindication to morphine
Patient’s refusal to participate in the study.