High Sensitivity Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease

About the study

This study will collect representative blood samples from healthy children and adults and from children and adults who have unique red blood cell features that are related to sickle cell disease. Sickle cell disease is a blood disease that limits the ability of red blood cells to carry oxygen throughout the body. The purpose of the study is to collect a variety of blood samples that may then be used to investigate advances and potential new drug treatments for sickle cell disease.

Volunteers must be at least 18 years of old. Samples will be taken both from healthy volunteers and from volunteers who have unique red blood cell features that are related to sickle cell disease. Candidates will be screened with a medical history.

During the study, participants will undergo a one- to two-hour outpatient procedure at the National Institutes of Health Clinical Center. Once researchers have explained the study and obtained the participant s consent, participants will donate 8 cc (approximately 2 teaspoons) of blood.

Because repeat testing helps researchers validate study findings, participants who have the unique red blood cell features mentioned above may also be asked if they are willing to return and donate another 2 cc to 8 cc of blood for additional studies. The amount of blood drawn will not exceed 50 ml with any eight-week period for adults or 7 cc within any six-week period for children.

Study point of contact

William A Eaton, M.D.
(301) 496-6030
[email protected]


> 18 Years

Study type




participation requirements

Patients with sickle cell trait
Patients with known hemoglobinopathies involving one or two genes for sickle hemoglobin
Healthy volunteers for control experiments
Age range: adults greater than or equal to 18 years of age

participation restrictions

Subjects who are unable to comprehend the investigational nature of the laboratory research are ineligible to enroll in this protocol.
As a safety precaution in handling the blood samples, patients with HIV, Hepatitis B or Hepatitis C will be excluded from the study. HIV, Hepatitis B or Hepatitits C testing will not be done under this study. Participants must be co-enrolled under another NIH protocol where the screening evaluation has been performed.

Last updated 2023-01-25