|Jérôme Stirnemann, Dr|
|+ 41 22 372 92 02|
|Jacques Serratrice, Dr|
> 8 Years
Patients aged 8 or over;
Diagnosed with a major SCD disorder (SS, SC, Hb O Arab, Sβ0 and Sβ+ -thalassemias);
Presentation of a Vaso-Occlusive Crisis (VOC), with or without Acute Chest Syndrome,
Unresponsive to level 2 analgesics (WHO classification)
Which fulfils the criteria necessary for consultation at an ED;
Ability to carry out the Valsalva manoeuvre;
Ability to give informed consent and sign a written informed consent form (consent and signature of legal guardian authorised).
Indication for artificial ventilation (non-invasive ventilation/oro-tracheal intubation);
Proven contraindication for HBOT established by a physician responsible for hyperbaric medicine;
Anomaly in the results of prior transcranial Doppler (TCD) ultrasound (> 200 cm/sec) or a previous history of stroke (but TCD will not be performed for the study);
Patients requiring more than 2 l/min of normobaric oxygen in order to maintain an SpO2 ≥ 92%.