Positron Emission Tomography (PET) Imaging of Vaso-occlusive Crisis(VOC) in Sickle Cell Disease (SCD).

About the study

The purpose of this study is to find objective biomarkers of vaso-occlusion (blood vessel blockage) in people with SCD. Using information from earlier studies and work being done, researchers have developed a strategy to image VOC, using positron emission tomography (PET).

The ability to see and measure VOC in SCD patients can help patient care, by showing when and how a VOC is occurring or going to occur. Studying this method will also help in future drug research, as it will allow researchers to deliver promising new medications that target hyper-adhesion and sickling in people with SCD.

Study point of contact

Jude Jonassaint, RN
919-219-7481
[email protected]
Leticia Candra, BA
[email protected]

Locations

64 United States sites

Age

> 18 Years

Phase

Phase 1

Study type

Interventional

Gender

All

Interventions

Radiation

Drug

participation requirements

Have a confirmed diagnosis of SCD (HbSS, SC, S/β-thalassemia, SD, SE, SO) by hemoglobin electrophoresis/High Performance Liquid Chromatography (HPLC)
Aged 18 and above
Ability to understand and provide informed consent.
If receiving hydroxyurea or L-glutamine, crizanlizumab, voxelotor or erythropoietin stimulating agents, must have been receiving the drug for at least 12 weeks prior to screening and plan to continue taking the drug at the same dose and schedule during the study
Experienced at least 2 VOCs leading to healthcare visit within the 12 months prior to screening visit as determined by medical history.

participation restrictions

Active malignancy
Current pregnancy or breast feeding
Participating in a chronic transfusion program (pre-planned series of transfusions for prophylactic purposes) and/or planning on undergoing an exchange transfusion during the duration of the study; episodic transfusion in response to worsened anemia or VOC is permitted
Received active treatment on another investigational trial within 30 days (or 5 half-lives of that agent, whichever is greater) prior to screening visit or plans to participate in another investigational drug trial

Locations

  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
  • Pittsburgh, Pennsylvania, United States, UPMC [Recruiting]
Last updated 2023-12-06