Red Blood Cell Survival Study: The Impact of Oxidative Stress on Erythrocyte Biology

About the study

This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood cells that survive post-transfusion compared to red blood cells transfused to a sickle cell patient from a donor without a G6PD enzyme deficiency.

Study point of contact

David Wichlan
919-966-6876
[email protected]

Locations

1 United States site

Age

18 to 60 Years

Phase

Phase 2

Study type

Interventional

Age

18 Years - 60 Years

Gender

All

Interventions

Biological

Compensation

Unknown

participation requirements

Age 18-60 years
HbSS/HbSβ0-thalassemia
Steady state (no pain or baseline pain and ≥1 month from any hospital admission)
Receiving chronic transfusions (i.e regular transfusion every 4-8 weeks).

participation restrictions

History of transfusion reactions not adequately managed by antihistamines
≥2 alloantibodies or warm autoantibodies
Known G6PD deficiency
Hepato- or splenomegaly
Participation in another therapeutic trial
Pregnant or nursing
HIV positive
At investigator discretion for uncontrolled inter-current illness or social situation limiting compliance with study requirements.
Inability to speak and/or read English

Locations

  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill, 27599 [Recruiting]
Last updated 2022-02-28