Red Blood Cell Survival Study: The Impact of Oxidative Stress on Erythrocyte Biology

About the study

This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood cells that survive post-transfusion compared to red blood cells transfused to a sickle cell patient from a donor without a G6PD enzyme deficiency.

Study point of contact

David Wichlan
919-966-6876
[email protected]

Locations

91 United States site

Age

18 Years - 60 Years

Phase

Phase 2

Study type

Interventional

Gender

All

Interventions

Biological

participation requirements

Age 18-60 years
Has diagnosis of sickle cell disease
Steady state (no pain or baseline pain and ≥1 month from any hospital admission)
Receiving chronic transfusions (i.e., regular transfusion every 4-8 weeks).

participation restrictions

History of transfusion reactions not adequately managed by antihistamines
Does not have crossmatch compatible red cells
Known G6PD deficiency
Hepato- or splenomegaly
Participation in another therapeutic trial
Pregnant or nursing
HIV positive
At investigator discretion for uncontrolled inter-current illness or social situation limiting compliance with study requirements.
Inability to speak and/or read English

Locations

  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]
  • Chapel Hill, North Carolina, United States, University of North Carolina at Chapel Hill [Recruiting]

MORE INFORMATION

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Last updated 2024-04-09