18 Years - 60 Years
Age 18-60 years
Has diagnosis of sickle cell disease
Steady state (no pain or baseline pain and ≥1 month from any hospital admission)
Receiving chronic transfusions (i.e., regular transfusion every 4-8 weeks).
History of transfusion reactions not adequately managed by antihistamines
Does not have crossmatch compatible red cells
Known G6PD deficiency
Hepato- or splenomegaly
Participation in another therapeutic trial
Pregnant or nursing
At investigator discretion for uncontrolled inter-current illness or social situation limiting compliance with study requirements.
Inability to speak and/or read English