RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell Disease

About the study

To determine the feasibility of matching donor red cells by RH genotype for a cohort of
chronically transfused patients with SCD.

Study point of contact

Stella Chou, MD
215-590-0947
[email protected]
Stacey Uter, BS
215-590-7722
[email protected]

Locations

1 United States site

Age

> 1 Years

Phase

Early Phase 1

Study type

Interventional

Gender

All

Interventions

Biological

Compensation

Unknown

participation requirements

– Subjects age >12 months

– Diagnosis of SCD, all genotypes

– Require a period of chronic red cell transfusion therapy

participation restrictions

– Rare RH genotype that would preclude identification of sufficient RBC units

– Antigen negative requirements due to alloimmunization that would preclude
identification of sufficient RBC units

– Alloimmunized to D antigen

– Rh alloimmunized patients for whom providing RH genotype matched blood would expose
the patient to an antigen that would not be consistent with standard of care and blood
bank protocols

Locations

  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia, 19104 [Recruiting]
Last updated 2021-03-10