RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell Disease

About the study

To determine the feasibility of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

Study point of contact

Stella Chou, MD
215-590-0947
[email protected]
Stacey Uter, BS
215-590-7722
[email protected]

Locations

1 United States site

Age

> 1 Years

Phase

Early Phase 1

Study type

Interventional

Age

1 Year -

Gender

All

Interventions

Biological

Compensation

Unknown

participation requirements

Subjects age >12 months
Diagnosis of SCD, all genotypes
Require a period of chronic red cell transfusion therapy

participation restrictions

Rare RH genotype that would preclude identification of sufficient RBC units
Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units
Alloimmunized to D antigen
Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols

Locations

  • Philadelphia, Pennsylvania, United States, Children's Hospital of Philadelphia, 19104 [Recruiting]
Last updated 2022-03-11