This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type D+ but have formed anti-D and are currently transfused with D- RBC (Red Blood Cell) units.
| Stella Chou, MD | |
| 215-590-0947 | |
[email protected] |
> 8 Years
Early Phase 1
Interventional
All
Biological
Subjects age > 8 years old
Diagnosis of SCD, all genotypes
Require chronic red cell transfusion therapy
History of anti-D
RH genotype predicts D+ expression
Rare RH genotype that would preclude sufficient RBC units
Antigen negative requirements due to alloimmunization that would preclude sufficient RBC units