Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease

About the study

Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain. The consequence is synthesis of altered haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation.

The aim of the study was to to investigate whether a combination of routine laboratory biomarkers of haemolysis could be used to predict VOC development in confirmed SCD patients.


> 18 Years

Study type

Observational [Patient Registry]





participation requirements

Sickle cell disease

participation restrictions

<18 years pregnancy Patient under protective guardianship or curatorship

Last updated 2022-05-17