The Effect of Exercise on Resting Biomarkers in Subjects With Sickle Cell Trait

About the study

This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and warfighters with SCT upon protracted, repeated, strenuous exertion. Changes in biomarkers post-exercise compared to pre-exercise (and compared to healthy controls) suggest activation of the associated pathway(s) which may contribute to exercise-related events in athletes and warfighters and subclinical complications in non-athletes.

Study point of contact

Tim R Randolph, PhD
[email protected]
Kitty Newsham, PhD
[email protected]


18 Years - 70 Years


Not Applicable

Study type






participation requirements

Sickle Cell Trait Group (AS)

Health subjects with sickle cell trait (AS)
Ages 18-70 years

Inclusion Criteria: Control group (AA)

Healthy subjects without sickle cell trait (AA)
Ages 18-70 years

participation restrictions

Sickle Cell Trait group (AS) AND healthy controls (AA).

Subjects will be excluded if they:

weigh less than 110 pounds,
are pregnant,
have hemoglobinopathies (other than sickle cell trait) as determined by Hb electrophoresis,
have other self-reported conditions known to cause blood coagulation activation, myocyte destruction, hemolysis, chronic inflammation, or renal disease
any condition that places subjects at risk during exercise.

Last updated 2023-01-25