Clinical Trials

Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.

Filters
Sort by
Stroke Registry for Children and Young Adults With Sickle Cell Disease in Nigeria – The Afolabi Stroke Registry

Sickle Cell Anemia (SCA) occurs in 300,000 newborns per year in the world, with 150,000 affected births in Nigeria, alone.

Locations

2 Nigeria sites

1 United States site

Age

5 to 26 Years

LEARN MORE
Stroke Prevention in Young Adults With Sickle Cell Anemia

Sickle cell disease (SCD) is the most common genetic disease, affecting about 25 million people worldwide.

Locations

1 United States site

1 Nigeria site

Age

16 to 26 Years

LEARN MORE
Pilot Study to Assess Patients’ and Health Workers’ Needs Involved in Sickle Cell Disease Management

This pilot research is aimed to assess the needs of patients and health workers involved in Sickle Cell Disease (SCD) management in Nigeria.

Locations

4 Nigeria sites

Age

> 18 Years

LEARN MORE
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Voxelotor (GBT440) in Pediatric Participants With Sickle Cell Disease

This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.

Locations

16 United States sites

5 Nigeria sites

4 Egypt sites

3 Italy sites

3 Kenya sites

3 United Kingdom sites

2 Oman sites

2 Ghana sites

2 Saudi Arabia sites

Age

2 to 14 Years

Phase

Phase 3

LEARN MORE
Validation of a Point-of-care Screening Tool for Children With Sickle Cell Disease

Sickle cell disease is very common in Nigeria.

Locations

4 United States sites

3 Nigeria sites

Age

6 to 60 Years

Phase

N/A

LEARN MORE
Management of Severe Acute Malnutrition in Children With Sickle Cell Disease Greater Than 5 Years of Age Living in Northern Nigeria

Except for children with HIV, all recommendations for treatment of childhood malnutrition are for children 5 years of age agree to participate over a 12-week period.

Locations

3 Nigeria sites

1 United States site

Age

5 to 12 Years

Phase

Phase 2

LEARN MORE
Point-of-Delivery Prenatal Test Results Through mHealth to Improve Birth Outcome

The investigators propose to adopt sustainable community networks (in this case churches) to implement an integrated community-based screening that incorporates mobile health technology (mHealth) to make prenatal test results available at the point-of-delivery to guide medical management.

Locations

1 Nigeria site

Age

> 18 Years

Phase

N/A

LEARN MORE
Hydroxyurea for Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa

The overall goal of the proposed study is to determine the effectiveness of hydroxyurea therapy for secondary stroke prevention and prevention of other neurological events in children with SCA with an acute overt stroke.

Locations

2 Nigeria sites

Age

1 to 16 Years

Phase

Phase 3

LEARN MORE
Risk Stratification for Clinical Severity of Sickle Cell Disease in Nigeria and Assessment of Efficacy and Safety During Treatment With Hydroxyurea

The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five.

Locations

1 Nigeria site

Age

> 18 Years

Genotypes

HbSS

Phase

Phase 4

LEARN MORE