Clinical Trials

Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.

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A Test of the Safety, Effectiveness, and Acceptability of an Improvised Dressing for Sickle Cell Leg Ulcers in a Tropical Climate

One in 300 Jamaicans have HbSS sickle cell disease, and of these, up to 70% will suffer from sickle cell leg ulcers (SCLUs).

Locations

1 Jamaica site

Age

13 to 70 Years

Genotypes

HbSS

Phase

N/A

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Neuropathic Pain in Jamaicans With Sickle Cell Disease

Pain is the most common component of the morbidity seen in sickle cell disease (SCD), and may be acute or chronic.

Locations

1 Jamaica site

Age

> 14 Years

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A Prospective Open Label, Pharmacokinetic Study of an Oral Hydroxyurea Solution in Children With Sickle Cell Anemia.

An open label, safety and pharmacokinetic study of oral hydroxyurea solution administered to children from 6 months to 17.

Locations

5 United Kingdom sites

1 Jamaica site

Age

6 to 17 Years

Genotypes

HbSS

Phase

Phase 2

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EXpanding Treatment for Existing Neurological Disease (EXTEND)

The primary goal of the Phase II EXTEND trial is to investigate the effects of open-label hydroxyurea treatment, escalated to maximum tolerated dose, for children with Sickle Cell Anemia and either conditional (170 - 199 cm/sec) or abnormal (≥200 cm/sec) Transcranial Doppler velocities.

Locations

1 Jamaica site

Age

2 to 17 Years

Genotypes

HbSS

Phase

Phase 2

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Gene Transfer for Patients With Sickle Cell Disease Using a Gamma Globin Lentivirus Vector: An Open Label Phase 1/2 Pilot Study

The purpose of this Phase 1/2 study is to determine the feasibility and safety of stem cell collection and gamma-globin gene transfer, and success of gene correction in subjects with sickle cell disease .

Locations

4 United States sites

1 Jamaica site

Age

18 to 45 Years

Phase

Phase 1/Phase 2

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A Phase 2 Study of the Efficacy of Antioxidant Therapy Compared With Enalapril in Slowing the Progression of Sickle Nephropathy in Children

The purpose of this study is to determine whether enalapril or antioxidant therapy (N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell disease and and its progression to sickle nephropathy .

Locations

1 Jamaica site

Age

2 to 18 Years

Phase

N/A

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