Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.
This clinical trial studies the effect of pre-transplant immunosuppression (PTIS) and donor stem cell transplant in treating patients with severe blood diseases (hemoglobinopathies).
1 United States site
2 to 30 Years
Early Phase 1
This is a study to evaluate the effect of voxelotor on daily physical activity and sleep quality, as measured by a wrist-worn device in participants with sickle cell disease (SCD) and chronic moderate anemia.
10 United States sites
12 to 55 Years
SCA
Phase 4
This study seeks to utilize an innovative approach of a single session problem-solving intervention to address psychosocial factors affecting patient outcomes within the pediatric sickle cell population.
1 United States site
> 7 Years
N/A
The purpose of the study is to assess the safety and tolerability of AG-946 in healthy volunteers after oral administration of single ascending doses (SAD) and multiple ascending doses (MAD) of AG-946 over 14 or 28 days of dosing, and to identify a range of doses that are safe and pharmacologically active in participants with sickle cell disease.
1 United States site
18 to 70 Years
Phase 1
The purpose of this research study is to compare two different ways to give opioid pain medicine to treat sickle cell disease pain that is bad enough to go to the emergency department for treatment.
6 United States sites
> 18 Years
Phase 3
The goal of the study is to evaluate the efficacy and safety of crizanlizumab in SCD patients with priapism.
17 United States sites
> 16 Years
HbSS, HbSC
Phase 2
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
17 United States sites
5 Nigeria sites
4 Egypt sites
4 United Kingdom sites
3 Italy sites
3 Kenya sites
2 Ghana sites
2 Oman sites
2 Saudi Arabia sites
1 France site
2 to 14 Years
SCA
Phase 3
The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters (non-elective infusion center/ER/hospital visits) or resulting in death over 12 months as compared with standard of care.
16 United States sites
> 18 Years
Phase 3
This study aims to enroll 58 pre-adolescent (<13 years) pediatric participants with sickle cell disease (SCD) who have a pre-adolescent sibling bone marrow donor.
11 United States sites
2 to 13 Years
HbSS
Phase 2
The purpose of this study is to compare the efficacy and safety of 2 doses of crizanlizumab (5.
9 United States sites
9 Brazil sites
6 United Kingdom sites
5 Italy sites
5 Germany sites
5 Belgium sites
4 Spain sites
3 Netherlands sites
3 Colombia sites
3 Greece sites
3 France sites
3 India sites
2 Panama sites
2 Canada sites
2 Lebanon sites
2 Turkey sites
1 South Africa site
1 Kenya site
1 United Arab Emirates site
1 Finland site
1 Ghana site
1 Jordan site
1 Oman site
> 12 Years
Phase 3
