Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.
The purpose of this project is to develop novel approaches to promote health and longevity while enhancing quality of life among persons with Sickle cell disease (SCD).
1 United States site
> 18 Years
N/A
The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients .
4 United States sites
5 to 50 Years
HbSS
A Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease .
10 United States sites
4 Tunisia sites
3 Lebanon sites
1 Greece site
1 Italy site
1 Netherlands site
1 Oman site
18 to 65 Years
HbSS
Phase 2
The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters (non-elective infusion center/ER/hospital visits) or resulting in death over 12 months as compared with standard of care.
15 United States sites
> 18 Years
Phase 3
The intent of this open-label, multicenter expanded access program (EAP) is to provide early access to voxelotor prior to market authorization .
18 United States sites
> 12 Years
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of SHP655 in participants with baseline health sickle cell disease (SCD) and SCD with acute vaso-occlusive crisis (VOC).
14 United States sites
18 to 65 Years
HbSS
Phase 1/Phase 2
The goal of the study is to compare the efficacy and safety of crizanlizumab + standard of care to standard of care alone on renal function in sickle cell disease patients ≥ 16 years with chronic kidney disease due to sickle cell nephropathy.
6 United States sites
5 Brazil sites
3 Italy sites
3 Spain sites
3 Turkey sites
2 France sites
2 Greece sites
2 United Kingdom sites
1 South Africa site
1 Netherlands site
> 16 Years
HbSS
Phase 2
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
16 United States sites
5 Nigeria sites
4 Egypt sites
3 Italy sites
3 Kenya sites
3 United Kingdom sites
2 Oman sites
2 Ghana sites
2 Saudi Arabia sites
2 to 14 Years
Phase 3
Approximately 60 subjects will be enrolled into this double-blind, placebo-controlled study for the Deferoxamine Intradermal Delivery Patch (DIDP).
4 United States sites
> 18 Years
SC
Phase 1/Phase 2
The purpose of this study is to assess the potential interventions of exercises in adults with sickle cell anemia (SCA) and cardiopulmonary disease; only including the more severe genotypes of sickle cell disease.
1 United States site
> 18 Years
N/A
