Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.
The trial of IV arginine therapy in children with Vaso-occlusive painful episodes (VOE) in sickle cell disease (SCD) is designed to further knowledge on efficacy and safety of the therapy.
10 United States sites
3 to 21 Years
Phase 3
African Americans living with chronic health conditions are more likely to experience depression and other mental health disorders than their healthy counterparts, and are more likely to experience severe depression than whites, but less likely to be diagnosed or receive treatment.
1 United States site
16 to 30 Years
N/A
This is a single arm pilot study of peripheral stem cell transplantation (PSCT) with ex vivo t-cell receptor alpha beta+(TCRαβ+) T cell and cluster of differentiation 19+ beta (CD19+ B) cell depletion of unrelated donor (URD) grafts using the CliniMACS device in patients with sickle cell disease (SCD) and beta thalassemia major (BTM).
1 United States site
2 to 25 Years
SS, SC
N/A
This study aims to enroll 58 pre-adolescent (<10 years) pediatric participants with sickle cell disease (SCD) who have a pre-adolescent sibling bone marrow donor.
11 United States sites
2 to 10 Years
Phase 2
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
16 United States sites
5 Nigeria sites
4 Egypt sites
3 Italy sites
3 Kenya sites
3 United Kingdom sites
2 Oman sites
2 Ghana sites
2 Saudi Arabia sites
2 to 14 Years
Phase 3
This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type D+ but have formed anti-D and are currently transfused with D- RBC (Red Blood Cell) units.
1 United States site
> 8 Years
Early Phase 1
To determine the feasibility of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
1 United States site
> 1 Years
Early Phase 1
The purpose of this study is to compare the efficacy and safety of 2 doses of crizanlizumab (5.
9 Brazil sites
9 United States sites
6 United Kingdom sites
5 Italy sites
5 Belgium sites
5 Germany sites
4 Spain sites
3 Netherlands sites
3 India sites
3 Greece sites
3 Colombia sites
3 France sites
2 Turkey sites
2 Canada sites
2 Panama sites
2 Lebanon sites
1 South Africa site
1 Jordan site
1 Ghana site
1 Finland site
1 Oman site
> 12 Years
Phase 3
MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease.
5 United States sites
> 18 Years
N/A
The intent of this open-label, multicenter expanded access program (EAP) is to provide early access to voxelotor prior to market authorization .
18 United States sites
> 12 Years
