Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.
Sickle cell disease (SCD) is the most common genetic disease, affecting about 25 million people worldwide.
1 United States site
1 Nigeria site
16 to 26 Years
With recent advances in gene editing, gene therapy is becoming a viable curative treatment option for sickle cell disease.
1 United States site
10 to 25 Years
Phase 2
Sickle Cell Anemia (SCA) occurs in 300,000 newborns per year in the world, with 150,000 affected births in Nigeria, alone.
2 Nigeria sites
1 United States site
5 to 26 Years
The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients .
4 United States sites
5 to 50 Years
HbSS
The overall purpose of this proposed study is to improve management of vaso-occlusive episodes (VOEs) in adult EDs.
8 United States sites
18 to 45 Years
SS, SC
N/A
This study will evaluate two genome-edited, autologous, hematopoietic stem and progenitor cell (HSPC) products - OTQ923 and HIX763 - each reducing the biologic activity of BCL11A, increasing fetal hemoglobin (HbF) and reducing complications of sickle cell disease.
3 United States sites
2 to 40 Years
HbSS, HbSC
Phase 1/Phase 2
This study is being done to test a transplant method that may have fewer side effects (or less toxic, less harmful) than conventional high dose chemotherapy conditioning-based transplants for children and young adults with Sickle Cell Disease (SCD).
1 United States site
2 to 25 Years
Phase 2
The primary objectives of this prospective mixed-method interview study are to use semi-structured interviews in parents of sickle cell disease (SCD) patients to describe parental attitudes of research involving genomic sequencing, including concerns about participation and expectations from researchers and to use surveys to quantitatively measure genetic/genomic knowledge, trust in health care provider, and literacy/numeracy ability in parents of children with SCD and adolescents with SCD.
1 United States site
> 13 Years
HbSS, HbSC
Open-label extension study of voxelotor for pediatric participants ages 4 to 18 years old with Sickle Cell Disease who have participated in voxelotor clinical trials.
7 United States sites
3 United Kingdom sites
2 Lebanon sites
4 to 18 Years
Phase 3
This project proposes to develop, test and evaluate targeted interventions to improve clinical provider prescribing of and patient adherence to hydroxyurea (HU).
8 United States sites
15 to 45 Years
SS, SC
N/A
