Clinical Trial Finder

Hundreds of clinical trials are rolled out around the world monthly, and many of them are designed to specifically uncover and manage the medical needs of people with sickle cell disease and trait. We keep an updated list of these global studies here, so you don’t have to go searching for them. There might be active study recruitment and enrollment happening at a site near you. Explore the list below to see the different types of studies, and use the navigation options on the left to get as specific as you would like.

Filters
Sort by
CHOICES for Sickle Cell Reproductive Health: Randomized Clinical Trial (RCT) of a Preconception Intervention Model for a Single Gene Disorder

The study will use web-based data collection (SCKnowIQ) and intervention delivery strategies enhanced by nudges and tailored boosters in a sample of 430 adult men and women, aged 18-45 yr with SCD (Sickle Cell Disease) or SCT (Sickle Cell Trait), at-risk, and planning within 2 years to have a child free of SCD.

Locations

157 United States sites

Age

18 Years - 45 Years

Phase

Not Applicable

LEARN MORE
Sickle Cell Improvement: Enhancing Care in the Emergency Department

Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 36,000 children in the United States, approximately 90% of whom are Black.

Locations

94 United States sites

Age

< 18 Years

Phase

Not Applicable

LEARN MORE
Revamping Exercise Assessments in Child Health (Project REACH)

This study is a cooperative investigation funded by the NIH.

Locations

94 United States sites

Age

10 Years - 17 Years

Phase

Not Applicable

LEARN MORE
Universal Genomic Newborn Screening in the Wallonia-Brussels Federation: Baby Detect

Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.

Locations

82 Belgium sites

Age

< 28 Days Years

LEARN MORE
Brain Structure and Neurocognitive Development in Sickle Cell Disease; a Longitudinal Cohort Study (BRICK Study)

Sickle cell disease (SCD) is an autosomal recessive red blood cell blood disorder.

Locations

184 Netherlands sites

Age

6 Years - 25 Years

LEARN MORE
The Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) Intervention: A Randomized Controlled Trial for Adolescents With Sickle Cell Disease to Prepare for Transition of Care

Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for transition of care.

Locations

89 United States sites

Age

10 Years - 18 Years

Phase

Phase 2

LEARN MORE
A Phase 3b Study to Evaluate Efficacy and Safety of a Single Dose of Autologous CRISPR Cas9 Modified CD34+ Human Hematopoietic Stem and Progenitor Cells (CTX001) in Subjects With Transfusion-Dependent β-Thalassemia or Severe Sickle Cell Disease

This is a single-dose, open-label study in participants with transfusion-dependent β-thalassemia (TDT) or severe sickle cell disease (SCD).

Locations

499 United States sites

167 Italy sites

116 Germany sites

Age

12 Years - 35 Years

Phase

Phase 3

LEARN MORE
A Phase 2/3 Randomized, Multicenter Study of GBT021601 Administered Orally to Participants With Sickle Cell Disease and an Open-Label Pharmacokinetics Study in Pediatric Participants With Sickle Cell Disease

The purpose of this study is to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of osivelotor.

Locations

1217 United States sites

182 Nigeria sites

61 Kenya site

48 Lebanon sites

Age

6 Months - 65 Years

Phase

Phase 2/Phase 3

LEARN MORE
Multicentric, Double-blind, Randomised Controled Trial of Hyperbaric-oxygen Therapy (HBOT) Versus Placebo for Treating Vaso-Occlusive Crisis (VOC) in Sickle Cell Disease (SCD) After 8 Years Old

This is a randomised, controlled, double-blind, placebo trial of HBOT (intervention) superiority in the treatment of VOC in SCD, to demonstrate the effectiveness of HBOT for the decrease in pain level in the treatment of SCD-VOC.

Locations

156 France sites

78 Switzerland sites

Age

> 8 Years

Phase

Phase 3

LEARN MORE
Dronabinol for the Reduction of Chronic Pain and Inflammation in People With Sickle Cell Disease

A randomized, double blind, study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).

Locations

86 United States sites

Age

> 18 Years

Phase

Phase 2

LEARN MORE